Hi,
I have discovered that FireFox does not support ClickOnce, rather ClickOnce does not support FireFox at this point in time. I realized the reason why was in all of FireFox's security it wont even allow the installer to access Windows System information, sometimes a thick thick lead wall can be a bad thing.
Anyways, my question is is there anyway, to get around that problem with maybe a different installer I think the problem comes when FireFox is the default browser, because even when running the Setup.exe file off of the local machine it fails but with IE set as defualt it runs with no problems.
So is there a work around

ClickOnce FireFox Replacement
Nagesh_techie
http://channel9.msdn.com/ShowPost.aspx PostID=138879
Muthu Arumugam
for kludge arounds and more excuses.
Read the blog comments the work arounds aren't that great.
Essentially if you want a professional seamless install, ClickOnce is not your product.
MDXXI
I have implemented this workaround on my site, if anyone wants to check out what the end prodcut looks like ...
www.slickscreen.com/program/publish.htm
Cheers- Brian Duper